New collaborative project “HybridADCC”

ADCCNew collaborative project “HybridADCC”

Clean Cells, a partner in an innovative project: “HybridADCC”

 

Clean Cells and its partners – OSE Immunotherapeutics SA, INSERM UMR1232/CNRSERL6001, the MicroPiCell platform[1]– have been granted with a €2,4M funding from the Fonds Unique Interministériel (FUI – cofunding from BpiFrance & the Pays de la Loire region) for a 36-month innovative project: “HybridADCC”.

This collaborative project, supported by Atlanpole Biotherapies biocluster, aims at developing a standardised ADCC (Antibody Dependent Cell-mediated Cytotoxicity) assay for testing mouse monoclonal antibodies in a human in vitro context, through the use of a hybrid human/mouse technology. The goal is to identify new antibodies and new therapeutic targets in the huge mouse antibody reservoir before moving these hints forward the human therapeutic field.

Capitalising on the success of Premium ADCC (development of a standardised tool to measure the ADCC activity of human antibodies), Clean Cells will provide its skills in cell culture and in the development of regulatory-compliant potency assays to:

  • Optimise manufacturing processes of the new hybrid effector cells while ensuring inter-lot homogeneity
  • Develop and evaluate innovative methods to measure the ADCC activity, potentially better suited for murine antibodies’ specific mechanisms

ritux-3 x40A0063

At the end of the 3-year research period, Clean Cells will be able to increase its portfolio of services for the characterisation of therapeutic antibodies and to offer manufacturing & commercialisation services of the hybrid human/mouse effector cells. Our customers will benefit from original tools for early assessment of mouse antibodies to discover new therapeutic targets and/or innovative modes of action.

 

For more information:

OSE Immunotherapeutics
INSERM UMR1232/CNRSERL6001

The MicroPiCell platform

 

[1] Part of the Structure Fédérative…

Catalogue Test

Our News & Events

  • Clean Cells’ Events

    Meet with Clean Cells. In the second quarter, join the Clean Cells’ team at: VIRAL SAFETY FOR BIOLOGICS, BIOMED…

  • Press Release

    VitamFero announces that Clean Cells has created a cell bank for its Toxo KO vaccine strain.

  • Clean Cells’ Events

    In the first quarter,
    join the Clean Cells’ team at:
    CELL & GENE THERAPY WORLD

  • New collaborative project “HybridADCC”

    Capitalising on the success of Premium ADCC, Clean Cells will provide its skills in cell culture and in the development of…

  • ACTIP MEETING

    Thursday 30 Nov, in Nantes, the ACTIP (Animal Cell Technology Industrial Platform) organized a meeting for its members.

  • Boost Your Brain

    “Boost your Brain” aim at providing information to our personnel about diverse topics concerning the biopharmaceutical field…

  • Clean Cells’ Events

    In the third quarter, join the Clean Cells’ team at : Regmed Europe and NLSDays

  • Clean Cells’ Events

    Meet with Clean Cells. In the first quarter, join the Clean Cells’ team at the Centennial Celebration of Bacteiophage research…

  • Clean Cells’ Events

    Meet with Clean Cells. In the first quarter, join the Clean Cells’ team at :
    BIOTECH SHOWCASE 2017…

  • Clean Cells’ Events

    Meet with Clean Cells. In the fourth quarter, join the Clean Cells’ team at :
    WORLD VACCINE CONGRESS…

  • Clean Cells’ Events

    In the third quarter, join the Clean Cells’ team at : ANTIBODY INDUSTRIAL SYMPOSIUM, EMBO CONFERENCE, BIOREGATE FORUM…

  • Clean Cells’ Newsletter

    Clean Cells is doing every to propose solutions that allow them to follow daily its activities. This is the reason why…

  • Of phages and men

    Clean Cells, as an authorized pharmaceutical facility, is now in position to offer its customers a wide panel of services for drug…

  • Clean Cells Tunes into Gene Therapy

    Clean Cells expands its service portfolio by tuning into gene therapy products since the beginning of 2015…

  • Clean Cells joins Come In Vendée

    Artists, merchants and companies from the Vendée that will unit to participate to the next Vendée Globe?…