Exosomes

Exosomes are part of the extracellular vesicle family. They are small, membrane-bound vesicles that are secreted by various cell types into the extracellular environment. They range in size from 30 to 150 nanometers and are found in many biological fluids, including blood, urine, saliva, and breast milk. Exosomes play a critical role in cell-to-cell communication by transporting proteins, lipids, and nucleic acids (such as RNA) between cells.

Exosomes contain various bioactive molecules that reflect the cell of origin. These include proteins, lipids, and different types of RNA (such as mRNA and miRNA). The specific cargo loaded into exosomes can influence the function and behavior of recipient cells.

Once released, exosomes travel through bodily fluids to reach target cells. They can be taken up by recipient cells through various mechanisms, including direct fusion with the cell membrane, endocytosis, or receptor-ligand interactions. This transfer of molecular content can modulate the physiological state of the recipient cells.

Challenges
& future directions

Standardizing the methods for producing and isolating exosomes is crucial for ensuring consistency and scalability in therapeutic applications.

In addition, comprehensive characterization of exosome composition and understanding their safety profile are essential to minimize risks and side effects.

As a key player in the field of both cell and gene therapies, Clean Cells has developed a great knowledge of regulatory guidelines and an important tool box to ensure the safety of cells that would be used as the production plant of the exosomes.

Moreover, thanks to its analytical development department, Clean Cells is able to accompany researchers and biotech companies in the development of analytical methods to get a suitable characterization of exosomes according to regulatory authority expectations.  

Exosomes _ Characterization

Clean Cells & Naobios
can support exosomes projects to go fast to clinics

In this short video, discover how Clean Biologics can support your exosomes drug-candidate project!

Therapeutic Potential of Exosomes

Exosomes have gained significant interest in the field of regenerative medicine and drug delivery due to their unique properties and versatile functions. They appear to be at the frontier between cell therapy and gene therapy.

They can be used in Regenerative Medicine. Exosomes derived from stem cells could be used in promoting tissue repair and regeneration. They can enhance cell proliferation, angiogenesis, and immune modulation, making them potential candidates for treating conditions such as cardiac injuries, neurological disorders, and wound healing.

Since they are naturally involved in the transport bioactive molecules, exosomes are being explored as drug delivery vehicles. They can be engineered to carry therapeutic agents, such as small molecules, RNA therapies, and proteins, to specific target cells, improving the efficacy and reducing the side effects of treatments.

Exosomes play a role in tumor progression and metastasis. Consequently, they could have an interesting potential for cancer therapy. By loading exosomes with anti-cancer drugs or therapeutic RNA, they could be used to target and kill cancer cells while minimizing damage to healthy tissue.

Exosomes can influence the immune system by carrying and presenting antigens, modulating immune responses, and delivering immunomodulatory molecules. This makes them potential tools for developing vaccines and therapies for autoimmune diseases and inflammatory conditions.

For more information, please do not hesitate to contact us.

"*" indicates required fields

RGPD